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교수소개

최수영
  • 분야

    생화학

  • 성명

    국문 최수영

  • 직위

    교수

  • 연구실

    자연과학대학 바이오메디컬학과 8409호

  • 연락처

    033-248-2112

  • 이메일

학력

1986 University of Tennessee, Knoxville, U.S.A (Ph.D-생화학) 
1982 연세대학교(이학석사-생화학) 
1980 연세대학교(이학사-생화학) 

주요경력

2014 ~ 현재 한국생화학분자생물학회 회장 
2013 ~ 현재 강원도 국제회의산업지원센터 이사장 
2012 ~ 2014 한림대학교 부총장 
2011 ~ 2011 한국생화학분자생물학회 부회장 
2010 ~ 2010 한국뇌신경과학회 회장 
2007 ~ 2010 한림대학교 부총장 
2006 ~ 현재 한국과학기술한림원 정회원 
2006 ~ 2010 생화학분자생물학회학술지(BMB Reports) 편집위원장 
2003 ~ 2007 한림대학교 교무연구처장 
2002 ~ 2013 춘천바이오산업진흥원 이사 
2002 ~ 2003 한림대학교 산학협력단장 
1998 ~ 1999 한림대학교 기획처장 
1994 ~ 1996 한림대학교 교무부처장 
1987 ~ 1988 University of California, Berkeley, U.S.A연구원 

연구 및 저서

논문 (2012-2017년도)

- H.Y.Jung, D.W.Kim, H.J.Kwon, D.Y.Yoo, I.K.Hwang, M.H.Won, T.G.Cho, S.Y.Choi, S.M.Moon

SUMO-1 does not protect against, but delays the neuronal damage in the spinal cord after ischemia/reperfusion. Molecular Medicine Reports In press (2017)

- D.Y.Yoo, D.W.Kim, H.J.Kwon, H.Y.Jung, S.M.Nam, J.W.Kim, J.Y.Chung, M.H.Won, Y.S.Yoon, S.Y.Choi, I.K.Hwang

Chronic administration of SUMO-1 has negative effects on novel object recognition memory as well as cell proliferation and neuroblast differentiation in the mouse dentate gyrus. Molecular Medicine Reports In press (2017)

- Expressions of G proteins, p-GATA4 and VEGF in hearts of transgenic mice overexpressing β1 and β2 adrenergic receptors. Molecular Medicine Reports In press (2017)

- J.H.Ahn, M.C.Shin, J.H.Park, I.H.Kim, J.H.Cho, T.K.Lee, J.C.Lee, B.H.Chen, B.N.Shin, H.J.Tae, J.Park, S.Y.Choi, Y.L.Lee, D.W.Kim, M.H.Won, J.H.Cho, M.H.Won

Effects of long-term post-ischemic treadmill exercise on gliosis in the aged gerbil hippocampus induced by transient cerebral ischemia. Molecular Medicine Reports In Press (2017)

- J.C.Lee, H.J.Tae, I.H.Kim, J.H.Cho, T.K.Lee, J.H.Park, J.H.Ahn, S.Y.Choi, B.H.Chen, B.N.Shin, G.S.Cho, D.W.Kim, I.J.Kang, Y.G.Kwon, Y.M.Kim, M.H.Won, E.J.Bae

Roles of HIF-1α, VEGF and NF-κB in ischemic preconditioning-mediated neuroprotection of hippocampal CA1 pyramidal neurons against a subsequent transient cerebral ischemia. Molecular Neurobiology In Press (2017)

- J.H.Ahn, S.k.Hong, H.J.Tae, J.Park, S.Y.Choi, J.H.Park, I.H.Kim, J.H.Cho, T.K.Lee, J.C.Lee, B.H.Chen, B.N.Shin, Y.L.Lee, Y.M.Kim, M.H.Won, E.J.Bae

Immunoreactivities of calbindin-D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging. Journal of Molecular Neuroscience In Press (2017)

- Neuroprotection and reduced gliosis by pre- and post-treatments of hydroquinone in a gerbil model of transient cerebral ischemiaJournal of Chemico-Biological Interactions In Press (2017)

- Lee, S.J. Kang, H.K. Eum, W.S. Park, J. Choi, S.Y. Kwon, H.Y.

Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress. Cell Biology International In Press (2017)

- E.A.Kim, J.M.Na, J.Kim, S.Y.Choi, J.Y.Ahn and S.W.Cho

Neuroprotective effect of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on brain ischaemia/reperfusion injury. Journal of Neuroimmune Pharmacology In Press (2017)

- J.H.Park, Y.H.Kim, J.H.Ahn, S.Y.Choi, S.k.Hong, S.K.kim, I.J.Kang, Y.M.Kim, T.K.Lee, M.H.Won, C.H.Lee

Atomoxetine protects against NMDA receptor-mediated hippocampal neuronal death following transient global cerebral ischemia. Current Neurovascular Research In Press (2017)

- Atomoxetine protects against NMDA receptor-mediated hippocampal neuronal death following transient global cerebral ischemia Current Neurovascular Research In Press (2017)

- J.Kim, C.H.Cho, H.G.Hahn, S.Y.Choi and S.W.Cho

Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus. Brain Research Bulletin 128, 22-28 (2017)

- H.S.Jo, D.W.Kim, M.J.Shin, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, H.J.Yeo, E.J.Sohn, O.Son, S.W.Cho, D.S.Kim, Y.H.Yu, K.W.Lee, J.Park, W.S.Eum, S.Y.Choi

Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway. Molecular Brain 10, 1-13 (2017)

- S.Y.An, G.S.Youn, H.Kim, S.Y.Choi and J.Park

Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-kB activation in poly(I:C)-stimulated astrocytes. BMB reports 50, 25-30 (2017)

- H.S.Jo, E.J.Yeo, M.J.Shin, Y.J.Choi, H.J.Yeo, S.B.Cho, J.H.Park, C.H.Lee, W.S.Eum, S.Y.Choi

Tat-DJ-1 enhances cell survival by inhibition of oxidative stress, NF-κB and MAPK activation in HepG2 cells. Biotechnology Letters 39, 511-521 (2017)

- E.A.Kim, C.H.Cho, S.Y.Choi, J.Y.Ahn, S.J.Yang, and S.W.Cho

2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride alters lipopolysaccharide-induced proinflammatory cytokines and neuronal morphology in mouse fetal brain. Neuropharmacology 102, 32-41 (2016)

- H.J.Kim, G.S.Youn, S.Y.An, H.Y.Kwon, S.Y.Choi, J.Park

2,3-dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells. BMB Reports 49(1), 57-62 (2016)

- S.H.Park, M.J.Shin, D.W.Kim, J.Park, S.Y.Choi, and Y.H.Kang

Blockade of monocyte-endothelial trafficking by transduced tat-superoxide dismutase protein. International Journal of Molecular Medicine 37, 387-397 (2016)

- N.K.Yu, H.F.Kim, J.Shim, S.Kim, D.W.Kim, C.Kwak, S.E.Sim, J.H.Choi, S.Ahn, J.Yoo, S.L.Choi, D.J.Jang, C.S.Lim, C.Kang, S.Y.Choi and B.K.Kaang

A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Scientific Reports 6(Article number:22892), 1-11 (2016)

- H.Y.Jung, D.W.Kim, H.S.Yim, D.Y.Yoo, J.W.Kim, M.H.Won, Y.S.Yoon, S.Y.Choi and I.K.Hwang

Heme Oxygenase-1 protects neurons from ischemic damage by upregulating expression of Cu,Zn-superoxide dismutase, catalase, and brain-derived neurotrophic factor in the rabbit spinal cord. Neurochemical Research 41, 869-879 (2016)

- C.H.Cho, E.A.Kim, J.Kim, S.Y.Choi, S.J.Yang and S.W.Cho

N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons Free Radical Research 50(6), 678-690 (2016)

- G.S.Youn, K.W.Lee, S.Y.Choi and J.Park

Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kB/AP-1 signalling pathways in macrophages. Free Radical Biology &Medicine 97, 14-23 (2016)

- H.S.Jo, H.J.Yeo, H.J.Cha, S.J.Kim, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, W.S.Eum, S.Y.Choi

Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death. BMB Reports 49(5), 297-302 (2016)

- J.H.Ahn, B.H.Chen, B.N.Shin, T.K.Lee, J.H.Cho, I.H.Kim, J.H.Park, J.C.Lee, H.J.Tae, C.H. Lee, M.H.Won, Y.L.Lee, S.Y.Choi, S.k.Hong

Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats. Molecular Medicine Reports 14(1), 851-856 (2016)

- E.H.Ahn, D.W.Kim, M.J.Shin, E.J.Ryu, J.I.Yong, S.Y.Chung, H.J.Cha, S.J.Kim, Y.J.Choi, D.S.Kim, S.W.Cho, K.Lee, Y.S.Cho, H.Y.Kwon, J.Park, W.S.Eum, S.Y.Choi

Tat-ATOX1 inhibits streptozotocin (STZ)-induced pancreatic RINm5F cell death and attenuates diabetes in a mice model International Journal of Molecular Medicine 38(1), 217-224 (2016)

- E.J.Sohn, M.J.Shin, W.S.Eum, D.W.Kim, J.I.Yong, E.J.Ryu, J.H.Park, S.B.Cho, H.J.Cha, S.J.Kim, H.J.Yeo, E.J.Yeo, Y.J.Choi, S.K.Im, H.Y.Kweon, D.S.Kim, Y.H.Yu, S.W.Cho, M.Park, J.Park, Y.J.Cho, S.Y.Choi

Tat-NOL3 protects against oxidative stress-induced hippocampal neuronal cell death by regulation of apoptotic pathways. International Journal of Molecular Medicine 38(1), 225-235 (2016)

- M.J.Shin, D.W.Kim, H.S.Jo, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, J.A.Kim, J.S.Hwang, E.J.Sohn, J.H.Jeong, D.S.Kim, H.Y.Kwon, Y.J.Cho, K.Lee, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults. Free Radical Biology &Medicine 97, 250-262 (2016)

- A.R.Goh, G.S.Youn, K.Y.Yoo, M.H.Won, S.Z.Han, S.S.Lim, K.W.Lee, S.Y.Choi and J.Park

Aronia melanocarpa concentrate ameliorates pro-inflammatory responses in HaCaT karatinocytes and 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice. Journal of Medicinal Food 19, 654-662 (2016)

- E.J.Sohn, M.J.Shin, D.W.Kim, O.Son, H.S.Jo, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, Y.H.Yu, D.S.Kim, S.W.Cho, O.S.Kwon, Y.J.Cho, J.Park, W.S.Eum, S.Y.Choi

PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage. BMB Reports 49, 382-387 (2016)

- S.M.Park, C.W.Park, T.K.Lee, J.H.Cho, J.H.Park, J.C.Lee, B.H.Chen, B.N.Shin, J.H.Ahn, H.J.Tae, M.C.Shin, T.G.Ohk, J.H.Cho, M.H.Won, S.Y.Choi, I.H.Kim

Effect of ischemic preconditioning on antioxidant status in the gerbil hippocampal CA1 region after transient forebrain ischemia. Neural Regeneration Research 11, 1081-1089 (2016)

- J.H.Ahn, J.H.Choi, J.H.Park, I.H.Kim, J.H.Cho, J.C.Lee, H.M.Koo, G.Hwangbo, K.Y.Yoo, C.H.Lee, I.K.Hwang, J.H.Cho, S.Y.Choi, Y.G.Kwon, Y.M.Kim, I.J.Kamng and M.H.Won

Long-term exercise improves memory deficits via restoration and microvessel damage, and enhancement of neurogenesis in the aged gerbil hippocampus after ischemic stroke. Neurorehabilitation &Neural Repair 30, 894-905 (2016)

- S.M.Yu, H.J.Yeo, S.Y.Choi and S.J Kim

Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways. The International Journal of Biochemistry &Cell Biology 80, 10-18 (2016)

- S.H.Eo, S.Y.Choi and S.J.Song

PEP-1-SIRT2-induced matrix metalloproteinase-1 and -13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes. Experimental Cell Research 348, 201-208 (2016)

- H.S.Jo, H.J.Cha, S.J.Kim, H.J.Yeo, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, W.S.Eum, S.Y.Choi

Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation. Medicinal Chemistry Research 25, 2589-2598 (2016)

- D.Y.Yoo, D.W.Kim, J.Y.Chung, H.Y.Jung, J.W.Kim, Y.S.Yoon, I.K.Hwang, G.M.Choi, S.Y. Choi and S.M.Moon

Cu,Zn-Superoxide Dismutase Increases the Therapeutic Potential of Adipose-derived Mesenchymal Stem Cells by Maintaining Antioxidant Enzyme Levels. Neurochemical

Research 41, 3300-3307 (2016)

- H.S.Jo, D.S.Kim, E.H.Ahn, D.W.Kim, M.J.Shin, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, H. J. Yeo, C.S.Y.Chung, S.W.Cho, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage and ischemic injury in an animal model. BMB reports 49, 617-622 (2016)

- J.H.Ahn, B.H.Chen, B.N.Shin, J.H.Cho, I.H.Kim, J.H.Park, J.C.Lee, H.J.Tae, Y.L.Lee, J.Lee, K.Byun, G.B.Jeong, B.Lee, S.U.Kim, Y.M.Kim, M.H.Won and S.Y.Choi

Intravenously infused F3.Olig2 improve memory deficits via restoring demyelination in the aged hippocampus following experimental ischemic stroke. Cell Transplantation 25, 2129-2144 (2016)

- D.Y.Yoo, D.W.Kim, M.J.Kim, J.H.Choi, H.Y.Jung, S.M.Nam, J.W.Kim, Y.S.Yoon, S.Y.Choi and I.K.Hwang

Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus. Neurological Research 37, 69-76 (2015)

- H.R.Kim, D.W.Kim, H.S.Jo, S.B.Cho, J.H.Park, C.H.Lee, Y.J.Choi, E.J.Yeo, S.Y.Park, S.T.Kim, Y.H.Yu, D.S.Kim, H.AKim, S.W.Cho, K.H.Han, J.Park, W.S.Eum and S.Y.Choi

Tat-Biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-kB pathways in Raw 264.7 cells and edema mouse model. Molecular Immunology 63, 355-366 (2015)

- J.C.Lee, B.H.Chen, J.H.Cho, I.H.Kim, J.H.Ahn, J.H.Park, H.J.Tae, G.S.Cho, B.C.Yan, D.W.Kim, I.K.Hwang, J.Park, Y.L.Lee, S.Y.Choi and M.H.Won

Changes in the expression of DNA-binding/differentiation protein inhibitors in neurons and glial cells of the gerbil hippocampus following transient global cerebral ischemia. Molecular Medicine Reports 11, 2477-2485 (2015)

- D.W.Kim, S.H.Lee, S.K.Ku, J.E.Lee, H.J.Cha, J.K.Youn, H.Y.Kwon, J.H.Park, E.Y.Park, S.W.Cho, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

The effects of PEP-1-FK506BP on dry eye disease in a rat model. BMB Reports 48, 151-156 (2015)

- S.M.Ju, G.S.Youn, Y.S.Cho, S.Y.Choi, J.Park

Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses via suppression of NF-κB activation in the RINm5F beta cells. BMB Reports 48, 172-177 (2015)

- J.C.Lee, H.J.Tae, G.S.Cho, J.H.Cho, I.H.Kim, J.H.Ahn, J.H.Park, B.H.Chen, B.N.Shin, J.H.Cho, J.Park, Y.M.Kim, S.Y.Choi and M.H.Won

Ischemic preconditioning protects neurons and maintains immunoreactivity of kynurenic acid in the gerbil hippocampal CA1 region following transient cerebral ischemia. International Journal of Molecular Medicine 35, 1537-1544 (2015)

- E.A.Kim, C.H.Cho, D.W.Kim, S.Y.Choi, J.W.Huh, and S.W.Cho

Antioxidative effects of ethyl 2-(3-(benzo[d]thiazol-2-yl)ureido)acetate against amyloid β-induced oxidative cell death via NF-κB, GSK-3β, and β-catenin signaling pathways in cultured cortical neurons. Free Radical Research 49, 411-421 (2015)

- S.J.Lee, H.K.Kang, D.K.Song, W.S.Eum, J.Park, S.Y.Choi, H.Y.Kwon

Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death. Biochemical Biophysical Research Communication 461, 549-554 (2015)

- E.J.Bae, B.H.Chen, B.N.Shin, J.H.Cho, I.H.Kim, J.H.Park, J.C.Lee, H.J.Tae, S.Y.Choi, J.D.Kim, Y.L.Lee, M.H.Won and J.H.Ahn

Comparison of immunoreactivities of calbindin-D28k, calretinin and paralbumin in the striatum between young and aged mice, rats and gerbils. Neurochemical Research 40, 864-872 (2015)

- S.M.Kim, I.K.Hwang, D.Y.Yoo, W.S.Eum, D.W.Kim, M.J.Shin, E.H.Ahn, H.S.Jo, E.J.Ryu, J.I.Yong, S.W.Cho, O.S.Kwon, K.W.Lee, Y.S.Cho, K.H.Han, J.Park, S.Y.Choi

Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischemic insult in animal model. Journal of Cellular and Molecular Medicine 19, 1333-1345 (2015)

- Y.N.Kim, D.W.Kim, H.S.Jo, M.J.Shin, E.H.Ahn, E.J.Ryu, J.I.Yong, H.J.Cha, S.J.Kim, H.J.Yeo, J.K.Youn, J.H.Hwang, J.H.Jeong, D.S.Kim, S.W.Cho, J.Park, W.S.Eum, S.Y.Choi

Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kB and MAPKs activation in macrophages and mice. Toxicology and Applied Pharmacology 286, 124-134 (2015)

- M.J.Kim, M.Park, D.W.Kim, M.J.Shin, O.Son, H.S.Jo, H.J.Yeo, S.B.Cho, J.H.Park, C.H.Lee, D.S.Kim, O.S.Kwon, J.Kim, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson’s disease model. Biomaterials 64, 45-56 (2015)

- S.A.Eom, D.W.Kim, M.J.Shin, E.H.Ahn, S.Y.Chung, E.J.Sohn, H.S.Jo, S.J.Jeon, D.S.Kim, H.Y.Kwon, S.W.Cho, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson’s disease. BMB Reports 48, 395-400 (2015)

- H.S.Hwang, I.YPark, D.W.Kim, S.Y.Choi and H.AKim

PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model. BMB Reports 48, 407-412 (2015)

- Y.Park, H.Kim, L.Park, D.Min, J.Park, S.Choi, M.H.Park

Effective delivery of endogenous antioxidants ameliorates diabetic nephropathy PLoS One 10(6), e0130815 (2015)

- W.Y.Seo, G.S.Youn, S.Y.Choi and J.Park

Butein, a tetrahydroxychalcone, supresses pro-inflammatory responses in HaCaT karatinocytes. BMB Reports 48, 495-500 (2015)

- E.S.Lee, H.J.Seo, S.S.Back, S.H.Han, Y.J.Jeong, J.W.Lee, S.Y.Choi and K.H.Han

Transcriptional regulation of Niemann-Pick C1 like 1(NPC1L1) gene by liver receptor homolog-1 (LRH-1). BMB Reports 48, 513-518 (2015)

- K.S.Yoon, S.M.Ju, S.Y.Choi and J.Park

HDAC6 mediates HIV-1 Tat-induced pro-inflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes. Glia 63(11), 1953-1965 (2015)

- S.J.Woo, M.J.Shin, D.W.Kim, H.S.Jo, J.Yong, E.J.Ryu, H.J.Cha, S.J.Kim, H.J.Yeo, S.B.Cho, J.H.Park, C.H.Lee, E.J.Yeo, Y.J.Choi, S.Park, S.K.Im, D.S.Kim, O.S.Kwon, J.Park, W.S.Eum, and S.Y.Choi

Effects of low doses of Tat-PIM2 protein against hippocampal neuronal cell survival. Journal of Neurological Science 358, 226-235 (2015)

- S.Hong, J.Y.Ahn, G.S.Cho, I.H.Kim, J.H.Cho, J.H.Ahn, J.H.Park, M.H.Won, B.H.Chen, B.N.Shin, H.J.Tae, S.M.Park, J.H.Cho, S.Y.Choi and J.C.Lee

Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia. Neural Regeneration Research 10, 1604-1611 (2015)

- J.C.Lee, H.J.Tae, B.H.Chen, J.H.Cho, I.H.Kim, J.H.Ahn, J.H.Park, B.N.Shin, H.Y.Lee, Y.S.Choe, J.H.Cho, S.Hong, S.Y.Choi, M.H.Won, C.W.Park

Failure in neuroprotection of remote limb ischemic postconditioning in the hippocampus of a gerbil model of transient cerebral ischemia. Journal of the Neurological Sciences 358, 377-384 (2015)

- E.A.Kim, C.H.Cho, J.Kim, H.G.Hahn, S.Y.Choi, S.J.Yang, and S.W.Cho

The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia. Neurotoxicology 51, 198-206 (2015)

- D.W.Kim, S.H.Lee, M.J.Shin, K.Kim, S.K.Ku, J.K.Youn, S.B. Cho, J.H.Park, C.H.Lee, O.Son, E.J.Sohn, S.W.Cho, J.H.Park, H.AKim, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury. BMB Reports 48, 618-623 (2015)

- S.H.Eo, D.W.Kim, S.Y.Choi, H.A.Kim, S.J.Kim

PEP-1-SIRT2 causes dedifferentiation and COX-2 expression via the MAPK pathways in rabbit articular chondrocytes. Experimental Cell Research 339, 351-359 (2015)

- Alessandro Matte, Luigia De Falco, Achille Iolascon, Narla Mohandas, Xiuli An, Angela Siciliano, Christophe Leboeuf, Anne Janin, Mariasole Bruno, Soo Young Choi, Dae Won Kim, and Lucia De Franceschi

The interplay between peroxyredoxin-2 and Nrf2 is important in limiting oxidative mediated dysfunction in β-thalassemic erythropoiesis. Antioxidants and Redox Signaling 23(16) 1284-1297 (2015)

- M.J.Shin, D.W.Kim, Y.P.Lee, E.H.Ahn, H.S.Jo, D.S.Kim, O.S.Kwon, T.C.Kang, Y.J.Cho, J.Park, W.S.Eum and S.Y.Choi

Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Free Radical Biology &Medicine 67, 195-210 (2014)

- W.Kim, D.W.Kim, H.J.Jeong, D.Y.Yoo, H.Y.Jung, S.M.Nam, J.H.Kim, J.H.Choi, M.H.Won, Y.S.Yoon, S.M.Moon, S.Y.Choi, I.K.Hwang

Tat-DJ-1 Protects Neurons from Ischemic Damage in the Ventral Horn of Rabbit Spinal Cord via Increasing Antioxidant Levels. Neurochemical Research 39, 187-193 (2014)

- M.J.Kim, H.J.Jeong, D.W.Kim, E.J.Sohn, H.S.Jo, D.S.Kim, H.A.Kim, E.Y.Park, J.H.Park, O.Son, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

PEP-1-PON1 protein regulates inflammatory response in Raw 264.7 macrophages and ameliorates TPA-induced animal model. PLoS One 9(1), e86034 (2014)

- Y.N.Kim, H.Y.Jung, W.S.Eum, D.W.Kim, M.J.Shin, E.H.Ahn, S.J. Kim, C.H.Lee, J.I.Yong, E.J.Ryu, J.Park, J.H.Choi, I.K.Hwang and S.Y.Choi

Neuroprotective effects of PEP-1-carbonyl reductase 1 (CBR1) against oxidative stress-induced ischemic neuronal cell damage. Free Radical Biology &Medicine 69, 181-196 (2014)

- E.J.Sohn, M.J.Shin, D.W.Kim, E.H.Ahn, H.S.Jo, D.S.Kim, S.W.Cho, K.H.Han, J.Park, W.S.Eum, H.S.Hwang, S.Y.Choi

Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson’s disease model. Molecules and Cells 37, 226-233 (2014)

- E.Y. Park, B.H.Kim, E.J.Lee, E.S.Chang, D.W.Kim, S.Y. Choi and J.H.Park

Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease. Journal of Biological Chemistry 289, 9254-9262 (2014)

372. E.H.Ahn, D.W.Kim, M.J.Shin, H.R.Kim, S.M.Kim, S.J.Woo, S.A.Eom,D.S.Kim, S.W.Cho, J.Park, W.S.Eum and S.Y.Choi

PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson’s disease. Biochimica Biophysica Acta (General Subject) 1840, 1686-1700 (2014)

- Seung-Ju Yang , Woo Je Lee, Eun-A Kim, Kee Dal Nam, Hoh-Gyu Hahn, Soo Young Choi, Sung-Woo Cho

Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. European Journal of Pharmacology 736, 26-34 (2014)

- H.J.Jeong, D.Y.Yoo, D.W.Kim, H.J.Yeo, S.B.Cho, J.Hyeon, J.H.Jung, J.Park, W.S.Eum, H.S.Hwang, M.H.Won, I.K.Hwang and S.Y.Choi

Neuroprotective effect of PEP-1-peroxiredoxin2 on CA1 regions in the hippocampus against ischemic insult. Biochimica Biophysica Acta (General Subject) 1840, 2321-2330 (2014)

- Meeyoung Park, Ehud Ohana, Soo Young Choi, Myeong-Sok Lee, Jong Hoon Park, and Shmuel Muall

Multiple Roles of the SO42-/Cl-/OH-exchangerSlc26a2inChondrocytefunctions.Journal of Biological Chemistry 289, 1993-2001 (2014)

- S.Y.Park, M.H.Kim, J.H.Ahn, S.J.Lee, J.H.Lee, W.S.Eum, S.Y.Choi and H.Y.Kwon

The stimulatory effect of fatty acids on glucose uptake involves both Akt and AMPK activation in C2C12 skeletal muscle cells. Krean Journal of Phisiology and Pharmacology 18, 255-261 (2014)

- Eun-A Kim, A Reum Han, Jiyoung Choi, Jee-Yin Ahn, Soo Young Choi, and Sung-Woo Cho

Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. International Immunopharmacology 22, 73-83 (2014)

- D.J.Kwon, Y.S.Bae, S.M.Ju, G.S.Youn, S.Y.Choi and J.Park

Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-<kappa>B activation in RAW 264.7 macrophages. BMB Reports 47, 318-323 (2014)

- E.J.Lee, S.A.song, H.W.Mun, K.H.Yoo, S.Y.Choi, E.Y.Park and J.H.Park

Blockage of Interleukin-8 receptor signaling inhibits cyst development in vitro, via suppression of cell proliferation in autosomal polycystic kidney disease. Nephrology 19, 471-478 (2014)

- Eun-A Kim, Jiyoung Choi, A Reum Han, Chang Hun Cho, Soo Young Choi, Jee-Yin Ahn, and Sung-Woo Cho

2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride inhibits microglial activation by suppression of nuclear factor-kappa B and mitogen-activated protein kinase signaling. Journal of Neuroimmune Pharmacology 9, 461-467 (2014)

- J.C.Lee, J.H.Cho, G.S.Cho, J.H.Ahn, J.H.Park, I.H.Kim, J.H.Cho, H.J.Tae, S.H.Cheon, J.Y.Ahn, J.Park, S.Y.Choi and M.H.Won

Effect of transient cerebral ischemia on the expression of receptor for advanced glycation end products (RAGE). Neurochemical Research 39, 1553-1563 (2014)

- S.J.Lee, J.D.Yoo, S.Y.Choi and O.S.Kwon

The expression and secretion of vimentin in the progression of non-alchoholic steatohepatitis. BMB Reports 47, 457-462 (2014)

- Eun-A Kim, Chang Hun Cho, Hoh-Gyu Hahn, Soo Young Choi, and Sung-Woo Cho

2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects against beta-amyloid-induced activation of the apoptotic cascade in cultured cortical neurons. Cellular and Molecular Neurobiology 34, 963-972 (2014)

- Gi Soo Youn, Dong-Joo Kwon, Sung Mi Ju, Hyangshuk Rhim, Yong Soo Bae, Soo Young Choi and Jinseu Park

Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and HO-1 induction in astrocytes. Toxicology and Applied Pharmacology 280, 42-52 (2014)

- H.J.Tae, J.H.Park, J.H.Cho, I.H.Kim, J.H.Ahn, J.C.Lee, J.D.Kim, J.Park, S.Y.Choi, M.H.Won

Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney. Chinese Medical Journal 127, 3758-3763 (2014)

- M.J.Chae, D.W.Kim, Y.J.Kim, H.Y.Kweon, Y.J.Cho, S.Y.Choi and H.R.Lee

Toxicity assessment of a novel silk fibroin and poly-methyl-methacrylate composite material. Molecular and Cellular Toxicology 10, 277-283 (2014)

- J.K.Youn, D.W.Kim, S.T.Kim, S.Y.Park, E.J.Yeo, Y.J.Choi, H.R.Lee, D.S.Kim, S.W. Cho, K.H.Han, J.Park, W.S.Eum, H.S.Hwang, S.YChoi

PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in Parkinson’s disease mouse model. BMB Reports 47, 569-574 (2014)

- H.J.Jeong, M.Y.Park, D.W.Kim, E.J.Ryu, J.I.Yong, H.J.Cha, S.J.Kim, H.J.Yeo, J.H.Jeong, D.S.Kim, H.C.Kim, E.J.Shin, E.Y.Park, J.H.Park, H.Y.Kwon, J.Park, W.S.Eum and S.Y.Choi

Downregulation of MAPK/NF-κB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model. International Immunopharmacology 23, 426-433 (2014)

- E.H.Ahn, D.W.Kim, M.J.Shin, Y.N.Kim, H.R.Kim, S.J.Woo, S.M.Kim, D.S. Kim, J.Kim, J.Park, W.S.Eum, H.S.Hwang, S.Y.Choi

PEP-1-ribosomal protein S3 protects dopaminergic neurons in MPTP-induced Parkinson’s disease mouse model. Free Radical Biology &Medicine 55, 36-45 (2013)

- M.J.Kim, D.W.Kim, B.R.Lee, M.J. Shin, Y.N.Kim, S.A.Eom, B.J.Park, Y.S.Cho, K.H. Han, J.Park, H.S.Hwang, W.S.Eum, S.Y.Choi

Transduced Tat-Glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model. Biochemical Biophysical Research Communication 430, 294-300 (2013)

- S.R.Jung, N.J.Song, D.K.Yang, Y.J.Cho, B.J.Kim, J.W.Hong, U.J.Yun, D.G.Jo, Y.M.Lee, S.Y.Choi and K.W.Park

Silk proteins stimulate osteoblast differentiation by suppressing the Notch signaling pathway in mesenchymal stem cells. Nutrition Research 33, 162-170 (2013)

I.G.Kyeong, W.S.Eum, S.Y.Choi and J.H.Kang

Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline. Toxicology Letter 217, 59-66 (2013)

- J.H.Ahn, M.H.Kim, H.J.Kwon, S.Y.Choi and H.Y.Kwon

Protective effects of oleic acid against palmitic acid-induced apoptosis in pancreatic AR42J cells and its mechanism. Korean Journal of Physiology and Pharmacology 17, 43-50 (2013)

- Sujin Lee , Jeong Han Kang, Soo Young Choi, Ki Tae Suk, Dong Joon Kim, Oh-Shin Kwon

PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. PLoS One 8(2): e55979 (2012)

- D.W.Kim, S.H.Lee, S.K.Ku, S.H.Cho, S.W.Cho, G.H.Yoon, H.S.Hwang, J.Park, W.S.Eum, O.S.Kwon and S.Y.Choi

Transduced PEP-1-FK506BP ameliorates corneal injury in Botulium toxin A-induced dry eye mouse model. BMB Reports 46, 124-129 (2013)

- W.S.Eum, K.J.Lee, D.W.Kim, S.S.Lim, I.J.Kang, J.Park and S.Y.Choi

Anti-Inflammatory effects of extracts from Caesalpinia sappan L. on skin inflammation. Journal of Korean Society Food Science and Nutrition 42, 384-388 (2013)

- S.H.Lee, J.K.Kim, D.W.Kim, H.S.Hwang, W.S.Eum, J.Park, K.H.Han, J.S.Oh, S.Y.Choi

Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells. Biochimica Biophysica Acta (General Subject) 1830, 4017-4029 (2013)

- Kim JE, Kim DS, Ryu HJ, Kim WI, Kim MJ, Kim DW, Choi SY, Kang TC.

The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus. Hippocampus. 23, 500-514 (2013)

- Su Sun Back, Jinsu Kim, Daehyung Choi, Eui Sup Lee, Soo Young Choi &Kyuhyung Han

Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor. BMB Report 46, 322-327 (2013)

- M.J.Kim, D.W.Kim, J.H.Park, S.J.Kim, C.H.Lee, J.I.Yong, E.J.Ryu, S.B.Cho, H.J.Yeo, J.Hyeon, S.W.Cho, D.S.Kim, O.Son, J.Park, K.H.Han, Y.S.Cho, W.S.Eum, S.Y.Choi

PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radical Biology &Medicine 63, 432-445 (2013)

- S.C.Ha, A.R.Han, D.W.Kim, E.A.Kim, D.S.Kim, S.Y.Choi, and S.W.Cho Neuroprotective effects of the antioxidant action of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against ischemic neuronal damage in the brain. BMB Reports 46, 370-375 (2013)

- Eun-A Kim, Jiyoung Choi, A Reum Han, Soo Young Choi, Hoh-Gyu Hahn, and Sung-Woo Cho

Anti-oxidative and anti-inflammatory effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on glutamate-induced neurotoxicity in rat brain. NeuroToxicology 38, 106-114 (2013)

- Youn GS, Kwon D-J, Ju SM, Choi SY, Park J.

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. BMB Reports. 46, 410-415 (2013)

D.J.Kwon, S.M.Ju, G.S.Yoon, S.Y.Choi and J.Park

Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-<kappa>B and AP-1 activation in RAW 264.7 macrophages. Food and Chemical Toxicology 58, 479-486 (2013)

- S.J.lee, J.H.Kang, S.Y.Choi and O.S.Kwon

PKCδ as a regulator for TGF-β stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells. Biochemical Journal 456, 109-118 (2013)

- Jung Hoon Choi, Dae Won Kim, Dae Young Yoo, Hoon Jae Jeong, Woosuk Kim, Hyo Young Jung, Sung Min Nam, Jong Hwi Kim, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang

Repeated Administration of PEP-1-Cu,Zn-Superoxide Dismutase and PEP-1-Peroxiredoxin-2 to Senescent Mice Induced by D-galactose Improves the Hippocampal Functions. Neurochemical Research 38, 2046-2055 (2013)

- Kim JH, Choi DJ, Jeong HK, Kim J, Kim DW, Choi SY, Park SM, Suh YH, Jou I, Joe EH.

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: a novel anti-inflammatory function of DJ-1. Neurobiology of Diseases 60, 1-10 (2013)

- Eun Hee Ahn, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Seon Ae Eom, Duk-Soo Kim, Eun Young Park, Jong Hoon Park, Sung-Woo Cho, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Choi

Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress through increasing its transduction efficiency. BMB Reports 46, 561-566 (2013)

- J.J.An,. W.S.Eum, H.S.Kwon, J.S.Koh, S.Y.Lee, J.H.Baek, Y.J.Cho, D.W.Kim, K.H.Han, J. Park, S.H.Jang and S.Y.Choi

Protective effects of skin permeable EGF and FGF1 against ultraviolet-induced skin damage and human skin wrinkles. Journal of Cosmetic Dermatology 12(4), 287-295 (2013)

- S.H.Lee, D.W.Kim, H.R.Kim, S.J.Woo, S.M.Kim, H.S.Jo, S.G.Jeon, S.W. Cho, J.H.Park, M.H.Won, J.Park, W.S.Eum and S.Y.Choi

Anti-inflammatory effects of transduced Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma. Biochemical Biophysical Research Communication 417, 1024-1029 (2012)

 

- J.E.Kim, H.J.Ryu, S.Y.Choi and T.C.Kang

Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus. Journal of Neuroinflammation 9, 6-18 (2012)

- D.W.Kim, H.S.Hwang, D.S.Kim, S.H.Sheen, D.H.Heo, G.Hwang, S.H.Kang, H.Y. Kweon, Y.Y.Jo, S.W.Kang, K.G.Lee, J.Park, W.S.Eum, Y.J.Cho, S.Y.Choi

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide. Journal of Microbiology and Biotechnology 22, 494-500 (2012)

- Sung Mi Ju, Ah Ra Goh, Dong-Joo Kwon, Gi Soo Youn, Hyung-Joo Kwon, Yong

Soo Bae, Soo Young Choi, and Jinseu Park

Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells. Molecules and Cells 33, 335-341 (2012)

- H.J.Jeong, D.W.Kim, S.J.Woo, H.R.Kim, S.M.Kim, H.S Jo, M.Park, D.S.Kim, O.S.Kwon, I.K.Hwang, K.H.Han, J.Park, W.S.Eum, S.Y.Choi

Transduced Tat-DJ-1 Protein Protects against Oxidative Stress-Induced SH-SY5Y Cell Death and Parkinson Disease in a Mouse Model. Molecules and Cells 33, 471-478 (2012)

Park JH, Lee CH, Yan BC, Ahn JH, Lee YJ, Park CW, Cho JH, Choi SY, Lee YL, Won MH, Lee HY.

Changes in ribosomal protein S3 immunoreactivity and its protein levels in the gerbil hippocampus following subacute and chronic restraint stress. Neurochemical Research 37, 1428-1435 (2012)

- Lee HY, Park JH, Lee CH, Yan B, Ahn JH, Lee YJ, Park CW, Cho JH, Choi SY, Won MH.

Changes of ribosomal protein S3 immunoreactivity and its new expression in microglia in the mice hippocampus after lipopolysaccharide treatment. Cellular and Molecular Neurobiology 32, 577-586 (2012)

- Yoo DY, Shin BN, Kim IH, Kim DW, Yoo KY, Kim W, Lee CH, Choi JH, Yoon YS, Choi SY, Won MH, Hwang IK.

Effects of sensitive to apoptosis gene protein on cell proliferation, neuroblast differentiation, and oxidative stress in the mouse dentate gyrus. Neurochemical Research 37, 495-502 (2012)

- Seong KM, Jung SO, Kim HD, Kim HJ, Jung YJ, Choi SY, and Kim J.

Yeast ribosomal protein S3 possesses a β-lyase activity on damaged DNA. FEBS Letters 586, 356-361, (2012)

- S.H.Lee, D.W.Kim, S.A.Eom, S.Y.Jun, M.Park, D.S.Kim, H.J.Kwon, H.Y.Kwon, K.H.Han, J.Park, H.S.Hwang, W.S.Eum and S.Y.Choi

Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein. BMB Reports 45, 354-359 (2012)

 

- E.J.Sohn, D.W.Kim, M.J.Kim, H.J.Jeong, M.J.Shin, E.H.Ahn, S.W.Kwon, Y.N.Kim, D.S.Kim, K.H.Han, J.Park. H.S.Hwang, W.S.Eum, S.Y.Choi

PEP-1-metallothionein-III protein ameliorates the oxidative stress-induced neuronal cell death and brain ischemic insults. Biochimica Biophysica Acta (General Subject) 1820, 1647-1655 (2012)

- Y.P.Lee, D.W.Kim, H.W.Kang, J.H.Hwang, H.J.Jeong, E.J.Sohn, M.J.Kim, E.H.Ahn, M.J.Shin, D.S.Kim, T.C.Kang, O.S. Kwon, S.W.Cho, J.Park, W.S.Eum and S.Y.Choi

PEP-1-heat shock protein 27 protects from neuronal damage in cells and in a Parkinson’s disease mouse model. FEBS Journal 279, 1929-1942 (2012)

- J.Y.Lee, S,Y,Choi, T,H,Oh, and T,Y. Yune

17β-Estradiol Inhibits Apoptotic Cell Death of Oligodendrocytes by Inhibiting RhoA-JNK3 Activation after Spinal Cord Injury. Endocrinology 153, 3815-3827 (2012)

- Eun-A Kim, Seung-Ju Yang, Soo Young Choi, Woo Je Lee, and Sung-Woo Cho

Inhibition of glutamate dehydrogenase and insulin secretion by KHG26377 does not involve ADP-ribosylation by SIRT4 or deacetylation by SIRT3. BMB Reports 45, 458-463 (2012)

- D.S.Kim, E.J.Sohn, D.W.Kim, Y.N.Kim, S.A.Eom, G.H.Yoon, S.W.Cho, S.H.Lee, H. S.Hwang, Y.S.Cho, J.Park,. W.S.Eum and S.Y.Choi

PEP-1-p18 prevents neuronal cell death via the inhibition of oxidative stress and Bax expression. BMB Reports 45, 532-537 (2012)

- D.Kim, M.C.Park, B.KPark, S.Kwon, J.H.Choi, H.J.Kim, S.Y.Choi, J.Park, Y.Lee and H.J.Kwon

Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells. BMB Reports 45, 538-543 (2012)

- M.J.Kim, D.W.Kim, H.J.Jeong, E.J.Sohn, M.J.Shin, E.H. Ahn, S.W.Kwon, Y.N.Kim, D.S.Kim, J.Park, W.S.Eum, H.S.Hwang and S.Y.Choi

Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson’s disease. Biochimie 94, 2448-2456 (2012)

- Dong-Joo Kwon, Young-Soo Bae, Sung Mi Ju, Ah Ra Goh, Gi Soo Youn, Soo Young Choi, and Jinseu Park

Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-<kappa>B and STAT1 activation in HaCaT cells. Biochemical Biophysical Research Communication 417, 1254-1259 (2012)

- D.Y.Yoo, B.N.Shin, I.H.Kim, W.Kim, D.W.Kim, K.Y.oo, J.H.Choi, C.H.Lee, Y.S.Yoon, S.Y.Choi, M.H.Won, I.K.Hwang

Effects of Cu,Zn-Superoxide Dismutase on Cell Proliferation and Neuroblast Differentiation in the Mouse Dentate Gyrus. Neurochemical Research 37, 261-267 (2012)

- Kim W, Kim DW, Yoo DY, Chung JY, Hwang IK, Won MH, Choi SY, Jeon SW, Jeong JH, Hwang HS, Moon SM.

Neuroprotective Effects of PEP-1-Cu,Zn-SOD against Ischemic Neuronal Damage in the Rabbit Spinal Cord. Neurochemical Research 37, 307-313 (2012)

- H.J.Son, S.C.Ha, E.Y.Hwang, E.A.Kim, J.Y.Ahn, S.Y.Choi and S.W.Cho

Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA. BMB Reports 45, 707-712 (2012)

기타

■ 주요연구주제
- 생화학(단백질생화학, 신경생화학) 
- 단백질침투기술( Protein Transduction Technology) 
- 단백질치료(Protein Therapy) 

 

■ 학회활동
- 한국생화학분자생물학회 
- 한국분자세포생물학회 
- 한국뇌신경과학회 
- 국제신경화학회 
- 한국유전학회 

 

■ 수상
- 과학기술우수논문상 (1996, 2004) 
- 대통령표창 (2001) 
- 강원인대상 (2005) 
- 강원도문화상 (2011) 
- 제6회 동곡상 (2011) 

 

홈페이지: http://web.hallym.ac.kr/~sychoi/

 

박진서
  • 분야

    면역학, 바이러스학

  • 성명

    국문 박진서

  • 직위

    교수

  • 연구실

    자연과학대학 바이오메디컬학과 8411호

  • 연락처

    033-248-2116

  • 이메일

학력

1987 ~ 1992 University of Alabama at Birmingham, USA (Ph.D-미생물학) 
1981 ~ 1983 한국과학기술원 (이학석사-생물공학과) 
1983 ~ 1987 연세대학교(이학사-식품공학과) 

 

주요경력

2013 ~ 현재 자연과학대학장 
2006 ~ 2013 바이오메디컬학과BK 단장 
2012 ~ 2013 바이오메디컬학과장 
2009 ~ 2012 연구처장 
2006 ~ 2012 산학협력단장 
2001 ~ 2002 Visiting Professor, Dept. of Cell Biology, University of Alabama at Birmingham, USA 
1994 ~ 현재Assistant Professor, Associate Professor, Professor, Dept. of Biomedical Science, College of Natural Sciences, Hallym University, Korea 
1992 ~ 1994 Post-Doctoral Fellow, Harvard Medical School, USA 

 

연구 및 저서

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells[BMB Reports, SCI급, 공동(교신), 2013] 
- Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages[Food and Chemical Toxicology, SCI급, 공동(교신), 2013] 

 

공동저자 : 공동저자(참여)
- Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency[BMB Reports, SCI급, 공동(참여), 2013] 
- Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells[BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, SCI급, 공동(참여), 2013] 
- Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model[BMB REPORTS, SCI급, 공동(참여), 2013] 
- PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson`s disease mouse model[FREE RADICAL BIOLOGY AND MEDICINE, SCI급, 공동(참여), 2013] 
- Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2013] 
- PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages[FREE RADICAL BIOLOGY AND MEDICINE, SCI급, 공동(참여), 2013] 
- TPA로 유도된 마우스 귀 부종 동물모델에서 소목추출물의 항염증 효과[한국식품영양과학회지, SCI급, 공동(참여), 2013] 
- Protective effects of skin permeable EGF and FGF1 against ultraviolet-induced skin damage and human skin wrinkles[Journal of Cosmetic Dermatology, SCI급, 공동(참여), 2013] 

기타

■ 주요연구주제
- Pathogenesis of AIDS by HIV, Development of therapeutic tools using protein transduction technology, Development of therapeutic materials against inflammatory diseases 


■ 학회활동
- The Korean Society of Virology 
- The Korean Society for Biochemistry and Molecular Biology 
- The Korean Society for Molecular Biology and Cell Biology 

한규형
  • 분야

    분자유전학

  • 성명

    국문 한규형

  • 직위

    교수

  • 연구실

    자연과학대학 바이오메디컬학과 8401호

  • 연락처

    033-248-2115

  • 이메일

학력

1986 ~ 1992 Columbia University, USA (Ph.D-생물학과) 
1981 ~ 1984 서울대학교(이학석사-미생물학과) 
1977 ~ 1981 서울대학교(이학사-미생물학과) 

주요경력

2013 ~ 현재 Pre-Med 협동전공과정주임교수 
2009 ~ 2011 바이오메디컬학과장 
2005 ~ 2009 생명공학연구소장 
1993 ~ 현재Assistant Professor, Associate Professor, Professor, Dept. of Biomedical Science, College of Natural Sciences, Hallym University, Korea 
1992 ~ 1993 Post-Doctoral Fellow, Cold Spring Harbor Laboratory, USA

연구 및 저서

■ 논문 : 주저자 : 제1저자, 공동저자(교신), 단독
- Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor[BMB Reports, SCI급, 공동(교신), 2013] 
논문 : 공동저자 : 공동저자(참여)
- Transduced Tat-glyoxalase protein attenuates sterptozotocin-induced diabetes in a mouse model[Biochemical and Biophysical Research Communications, SCI급, 공동(참여), 2013] 
- PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes inmurinemacrophages[Free Radical Biology and Medicine, SCI급, 공동(참여), 2013] 
- Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells[Biochimica et Biophysica Acta, SCI급, 공동(참여), 2013] 
- Protective effects of skin permeable EGF and FGF1 against ultraviolet-induced skin damage and human skin wrinkles[Journal of Cosmetic Dermatology, SCI급, 공동(참여), 2013] 

기타

■ 주요연구주제
- Transcriptional gene regulation, Gene regulation by siRNA


■ 학회활동
- The Korean Society for Molecular Biology and Cell Biology


■ 수상
- 중소기업청장상 (2011) 
- 교외 연구비 수혜현황 (연구책임자 기준)

조윤신
  • 분야

    미생물학

  • 성명

    국문 조윤신

  • 직위

    교수

  • 연구실

    자연과학대학 바이오메디컬학과 8407호

  • 연락처

    033-248-2111

  • 이메일

학력

1996 ~ 2001 미국 일리노이대학교 분자생물학전공 (박사) 
1993 ~ 1996 미국 위스콘신대학교 미생물학전공 (석사) 
1984 ~ 1986 서강대학교 생물학전공 (석사) 
1980 ~ 1984 서강대학교 생물학전공 (학사) 

주요경력

2013 ~ 현재 한림대학교 BK21 플러스 사업팀장 
2013 ~ 현재 한림대학교 바이오메디컬학과장 
2013 ~ 현재 질병관리본부 보건의료기술 평가관리 전문위원회 위원 
2013 ~ 현재 질병관리본부 자료·자원활용심의 위원회 위원 
2012 ~ 현재 한국연구재단 생명과학단 전문위원 (Review Board) 
2012 ~ 현재 한국과학기술한림원 선도과학자 
2012 ~ 2013 Pre-Med협동과정주임교수 
2012 ~ 현재 한림대학교 자연과학대학 바이오메디컬학과 교수 
2009 ~ 2011 질병관리본부 국립보건연구원유전체센터 보건연구관 
2006 ~ 2009 질병관리본부 국립보건연구원유전체센터 책임연구원 
2004 ~ 2006 한양대학교 생명과학과 연구교수 
2001 ~ 2004 미국 펜실베니아대 의과대학, 박사후과정 연구원 
1989 ~ 1991 한림대학교 유전공학과 전임조교 

연구 및 저서

■ 논문 : 주저자 : 제1저자, 공동저자(교신), 단독
- Genotype instability during long-term subculture of lymphoblastoid cell lines[JOURNAL OF HUMAN GENETICS, SCI급, 공동(교신), 2013] 
- New susceptibility loci in MYL2, C12orf51 and OAS1 associatedwith 1-h plasma glucose as prediposing risk factors for type 2 diabetes in the Korean population[JOURNAL OF HUMAN GENETICS, SCI급, 공동(교신), 2013] 
논문 : 공동저자 : 공동저자(참여)
- Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders[NATURE GENETICS, SCI급, 공동(참여), 2013] 
- Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India[DIABETES, SCI급, 공동(참여), 2013] 
- Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci[HYPERTENSION, SCI급, 공동(참여), 2013] 
- Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4[DIABETOLOGIA, SCI급, 공동(참여), 2013] 
- Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2013] 
- PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages[FREE RADICAL BIOLOGY AND MEDICINE, SCI급, 공동(참여), 2013] 
- Hwang JY, Lee SH, Go MJ, Kim BJ, Kou I, Ikegawa S, Guo Y, Deng HW, Raychaudhuri S, Kim YJ, Oh JH, Kim Y, Moon S, Kim DJ, Koo H, Cha MJ, Lee MH, Yun JY, Yoo HS, Kang YA, Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture[JOURNAL OF MEDICAL GENETICS, SCI급, 공동(참여), 2013] 교외 연구비 수혜현황 (연구책임자 기준) 

기타

■ 주요연구주제
- 유전체연구


■ 학회활동
- 한국유전체학회 
- 생화학분자생물학회 

이근욱
  • 분야

    암생물학

  • 성명

    국문 이근욱

  • 직위

    교수

  • 연구실

    자연과학대관 8411호

  • 연락처

    033-248-2113

  • 이메일

학력

2005 연세대학교 생화학과 (이학박사) 
1997 연세대학교 생화학과 (이학석사) 
1995 연세대학교 생화학과 (이학사)

주요경력

2014 ~ 현재 한림대학교 바이오메디컬학과 (조교수) 
2013 ~ 2014 연세대학교 의과대학 의생명과학부 (연구교수) 
2011 ~ 2013 Department of Pathology, Microbiology &Immunology, Vanderbilt University (Research Instructor) 
2006 ~ 2011 Department of Pathology, Microbiology &Immunology, Vanderbilt University (Research Fellow) 
2005 ~ 2006 한림대학교 의과학연구소 (연구강사)

 

연구 및 저서

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Lee, K., Heffington, L., Jellusova, J., Nam, K.T., Raybuck, A., Cho, S.H., Rickert, R., and Boothby, M. (2013) Requirement for Rictor in homeostasis and function of mature B lymphoid cells. Blood. 122: 2369-2379. 
- Lee, K., Boyd, K.L. Parekh, D.V., Kehl-Fie, T.E., Baldwin, H.S., Brakebusch, C., Skaar, E.P., Boothby, M. and Zent, R. (2013) Cdc42 promotes host defenses against fatal infection. Infect. Immun. 81:2714-2723.


공동저자 : 공동저자(참여)
- McGuire, V.A., Gray, A., Monk, C.E., Santos, S.G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I.H., Leslie, N.R., Dean, J.L.E., O’Keefe, S.J., Boothby, M., Gaestel, M., and Arthur, J.S. (2013) Crosstalk between Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol. Cell. Biol. 33: 4152-4156. 
- Williams, C.L., Schilling, M., Cho, S.H., Lee, K., Wei, M., Aditi, and Boothby, M. (2013) STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. J. Immunol. 191:678-687. 
- Rosborough, B.R., Raïch-Regué D., Matta, B.M., Lee, K., Gan, B., DePinho, R.A., Hackstein, H., Boothby, M., Turnquist, H.R., and Thomson, A.W. (2013) Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood. 121:3619-3630

기타

■ 주요연구주제
- mTOR signaling and lymphocyte function 
- mTOR signaling and leukemia development 

 

■ 학회활동
- American Association of Immunologist 
- 대한면역학회